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KMID : 0613820050150010087
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Journal of Life Science
2005 Volume.15 No. 1 p.87 ~ p.93
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Effects of Different Exercise Intensities on GRP-78 and GLUT-4 Expression in Soleus Muscle of Streptozotocin-Induced Diabetic Rats
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Kim Yang-Hee
Yoon Jin-Hwan
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Abstract
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This study investigated the response of GLUT-4 and GRP-78 expression in soleus muscle of streptozotocin-induced diabetic rats by imposing different exercise intensities. F344 rats were randomly divided into 4 groups (n=15 in each group): Control (Control), diabetes-operation (DO), diabetes with low intensity exercise (DLE) and diabetes with high intensity exercise (DHE). The rats in DLE and DHE groups were exercised for 8 weeks by treadmill running. Blood glucose levels in DO were significantly higher compared to that in NORMAL whereas DLE showed the most lowest level in blood glucose among diabetic groups. Diabetic groups exhibited significantly lower level in insulin change and DLE showed significantly higher insulin level among diabetic groups. GRP-78 in DO was significantly (167.05%) higher than that in Control. GRP-78 in DLE was 139.41% which is significantly higher compared to Control but when compared to DO and DHE, it was significant low. GRP-78 in DHE was 194.64% which doubled the protein level in Control and showed the most highest level in all groups. GLUT-4 in DO was significantly (33.58%) higher compared to Control. GLUT-4 in DLE showed 124.58% which was significant high compared to Control, DO and DHE. GLUT-4 in DHE showed 26.91% compared to Control and was the most lowest level among all groups. It seems clear that chiefly low intensity exercise benefits diabetic patients in controlling blood glucose. It was concluded that low intensity exercise induces translocation of GLUT-4 which results in increased blood inflow, thus GRP-78 expression is decreased.
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KEYWORD
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